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진료과

  • 용인세브란스병원-소화기내과

전문진료분야

  • <소화기내과> 급만성 간염(B, C형, 자가면역성 등), 알코올성 간질환, 지방간질환, 원발성 담즙성 간경변, 원인 미상의 만성 간질환, 급성 간부전, 간경변, 간세포암, 세포치료, 황달

교육 및 임상 경력

  • 세브란스병원  수련의,  전공의  수료
  • 내과전문의
  • 세브란스병원  소화기내과  강사
  • 일본  야마구치대학  소화기내과,  재생의학과  단기연수
  • 세브란스병원  세포치료센터  임상전임강사
  • 소화기내과  분과전문의
  • 소화기내시경전문의
  • 강남세브란스  소화기내과  부교수
  • 용인세브란스  소화기내과  교수

학술관련경력

  • 대한의학협회 회원
  • 대한내과학회 회원
  • 대한소화기내시경학회 평생회원
  • 대한 소화기학회 평생회원
  • 대한간학회 정회원
  • 대한간암연구회 평생회원
  • 줄기세포학회 회원

주요 관심분야

  • 간염, 간경변, 간암, 세포치료, 임상연구

학력사항

  • 연세대학교 의과대학 의학과 학사
  • 연세대학교 대학원 의학과 석사
  • 연세대학교 대학원 의학과 박사

논문

  • 한국인에서 전격성 간부전의 임상적 특징 및 예후 인자
    The Korean Journal of Hepatology(대한간학회지) 10/4 :298-307,2004
  • Usefulness of urine strip test in the rapid diagnosis of spontaneous bacterial peritonitis
    LIVER INTERNATIONAL 25/ :1197-1201,2005
  • 라미부딘으로 유도된 b형 간염 표면항원 소실 예에서의 간내 바이러스 양상
    대한내과학회지(korean Journal of medcine) 71/ :s998-s1002,2006
  • 하대정맥 침습 또는 심방 종양혈전증을 보이는 진행 간세포암종의 임상 특징과 치료에 따른 예후
    The Korean Journal of Hepatology(대한간학회지) 13/3 :387-395,2007
  • Role of(18)F-Fluorodeoxyglucose positron Emission Tomography in detecting Extrahepatic Metastasisin pretreatment staging of hin pretreatment staging of hepatocellular carcinoma
    ONCOLOGY 72/S1 :104-110,2007
  • PIVKA-II is a useful tumor marker for recurrent hepatocellular carcinoma after surgical resection
    ONCOLOGY 72/S1 :52-57,2007
  • Changes in serum and ascitic monocyte chemotactic protein-1 (MCP-1) and IL-10 levels in cirrhotic patients with spontaneous bacterial peritonitis
    JOURNAL OF INTERFERON AND CYTOKINE RESEARCH 27/ :227-230,2007
  • Liver cancer in Korea
    HEPATOLOGY RESEARCH 37S2/ :S106-S109,2007
  • Anti-hepatitis A virus seroprevalence among patients with chronic viral liver disease in Korea
    EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY 19/11 :923-926,2007
  • Persistent hepatitis B viral replication affects recurrence of hepatocellular carcinoma after curative resection
    Liver International 28/ :393-401,2008
  • Pilot clinical trial of localized concurrent chemoradiation therapy for locally advanced hepatocellular carcinoma with portal vein thrombosis
    Cancer 113/5 :995-1003,2008
  • MDM2 and p53 polymorphisms are associated with the development of hepatocellular carcinoma in patients with chronic hepatitis B virus infection
    Carcinogenesis 29/ :1192-1196,2008
  • Specific Mutations in the Enhancer II/Core Promoter/Precore Regions of Hepatitis B Virus Subgenotype C2 in Korean Patients With Hepatocellular Carcinoma
    Journal Of Medical Virology 81/6 :1002-1008,2009
  • Hepatitis B e Antigen-Negative Mutations in the Precore and Core Promoter Regions in Korean Patients
    Journal Of Medical Virology 81/4 :594-601,2009
  • Variability in liver stiffness values from different intercostal spaces
    Liver International 29/5 :760-766,2009
  • 간부전 환자에서 MARS? (Molecular Adsorbents Recirculating System)을 이용한 체외 간 지지요법의 유용성과 안정성에 대한 예비 결과
    Korean Journal Of Gastroenterology 54/1 :28-35,2009
  • Rescue monotherapy in lamivudine-resistant hepatitis B e antigen-positive chronic hepatitis B: Adefovir versus entecavir
    Antiviral Therapy 14/5 :705-712,2009
  • celecoxib induces hepatic stellate cell apoptosis through inhibition of Akt activation and suppresses hepatic fibrosis in rats.
    Gut 58/ :1517-1527,2009
  • Recombinant interferon-Beta-1 a plus ribavirin for the treatment of chronic HCV infection: A prospective, randomized, comparative pilot study
    GUT AND LIVER 3/1 :20-25,2009
  • Reactivation of Hepatitis B Viral Infection in Inactive HBsAg Carriers Following Anti-Tumor Necrosis Factor-alpha Therapy
    Journal Of Rheumatology 36/11 :2416-2420,2009
  • Current status of liver diseases in Korea: hepatitis B
    The Korean Journal Of Hepatology(대한간학회지) 15/16 :s13-s24,2009
  • A Liver Stiffness Measurement-Based, Noninvasive Prediction Model for High-Risk Esophageal Varices in B-Viral Liver Cirrhosis
    American Journal of Gastroenterology 105/6 :1382-1390,2010
  • Prospective validation of P2/MS noninvasive index using complete blood counts for detecting oesophageal varices in B-viral cirrhosis
    LIVER INTERNATIONAL 30/6 :860-866,2010
  • 생검으로 진단된 간의 혈관근지방종 1예
    Korean Journal Of Medicine 79/3 :295-300,2010
  • Clinical Efficacy of a 24-months Course of Lamivudine Therapy in Patients with HBeAg Negative Chronic Hepatitis B: A Long-term Prospective Study
    JOURNAL OF KOREAN MEDICAL SCIENCE 25/6 :882-887,2010
  • How Can We Enhance the Performance of Liver Stiffness Measurement Using FibroScan in Diagnosing Liver Cirrhosis in Patients With Chronic Hepatitis B?
    Journal Of Clinical Gastroenterology 44/1 :66-71,2010
  • Association Between Polymorphism of Tumor Necrosis Factor-alpha Promoter and Response to Lamivudine Treatment in Patients with Chronic Hepatitis B
    Digestive Diseases And Sciences 55/7 :2043-2048,2010
  • A novel liver stiffness measurement-based prediction model for cirrhosis in hepatitis B patients
    LIVER INTERNATIONAL 30/7 :1073-1081,2010
  • External Validation of P2/MS and Comparison with Other Simple Non-invasive Indices for Predicting Liver Fibrosis in HBV-Infected Patients
    Digestive Diseases And Sciences 55/9 :2636-2643,2010
  • Validation of FIB-4 and comparison with other simple noninvasive indices for predicting liver fibrosis and cirrhosis in hepatitis B virus-infected patients
    LIVER INTERNATIONAL 30/4 :546-553,2010
  • Factors that affect the diagnostic accuracy of liver fibrosis measurement by Fibroscan in patients with chronic hepatitis B
    Alimentary Pharmacology & Therapeutics 32/3 :498-505,2010
  • Autologous Bone Marrow Infusion Activates the Progenitor Cell Compartment in Patients With Advanced Liver Cirrhosis
    Cell Transplantation 19/10 :1237-1246,2010
  • 급성 신기능 손상을 동반한 A형 간염
    The Korean Journal Of Gastroenterology 56/6 :391-393,2010
  • Toll-like Receptor Polymorphisms are not Associated with Liver Cirrhosis in Hepatitis B Virus Infected Korean Patients
    Hepato-Gastroenterology 57/104 :1351-1355,2010
  • Long-term clinical outcomes of hepatic arterial infusion chemotherapy with cisplatin with or without 5-fluorouracil in locally advanced hepatocellular carcinoma
    JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY 137/4 :659-667,2011
  • Percutaneous cryoablation of small hepatocellular carcinomas using a 17-gauge ultrathin probe
    CLINICAL RADIOLOGY 66/8 :752-759,2011
  • The usefulness of liver stiffness measurement using FibroScan in chronic hepatitis C in South Korea: A multicenter, prospective study
    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 26/1 :171-178,2011
  • Risk Assessment of Esophageal Variceal Bleeding in B-Viral Liver Cirrhosis by a Liver Stiffness Measurement-Based Model
    AMERICAN JOURNAL OF GASTROENTEROLOGY 106/9 :1654-1662,2011
  • Partial virological response to entecavir in treatment-naive patients with chronic hepatitis B
    ANTIVIRAL THERAPY 16/4 :469-477,2011
  • Antifibrotic effects of magnesium lithospermate B on hepatic stellate cells and thioacetamide-induced cirrhotic rats
    EXPERIMENTAL AND MOLECULAR MEDICINE 43/6 :341-349,2011
  • 18F-fluorodeoxyglucose uptake on positron emission tomography as a prognostic predictor in locally advanced hepatocellular carcinoma
    CANCER 117/0 :4779-4787,2011
  • Early α-fetoprotein response as a predictor for clinical outcome after localized concurrent chemoradiotherapy for advanced hepatocellular carcinoma
    LIVER INTERNATIONAL 31/3 :369-376,2011
  • 복강 내 종양으로 오인된 농양을 형성한 위궤양 천공 1예
    Korean J Med 81/1 :89-92,2011
  • Suppression of Innate Immunity (Natural Killer Cell/Interferon-gamma) in the Advanced Stages of Liver Fibrosis in Mice
    HEPATOLOGY 53/4 :1342-1351,2011
  • Clinical characteristics of acute hepatitis A complicated by acute kidney injury
    SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES 44/ :144-148,2012
  • Transitional features of histologic type of non-alcoholic fatty liver disease in Korean young men
    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 27/ :142-148,2012
  • Clinical characteristics and prognosis of hepatocellular carcinoma with different sets of serum AFP and PIVKA-II levels
    EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY 24/7 :849-856,2012
  • A Case of Acute Disseminated Encephalomyelitis Associated with Hepatitis C Virus Infection
    YONSEI MEDICAL JOURNAL 53/4 :856-858,2012
  • Discordance between Liver Biopsy and FibroScan (R) in Assessing Liver Fibrosis in Chronic Hepatitis B: Risk Factors and Influence of Necroinflammation
    PLOS ONE 7/2 :e32233-e32233,2012
  • Combination of preS Deletions and A1762T/G1764A Mutations in HBV Subgenotype C2 Increases the Risk of Developing HCC
    INTERVIROLOGY 55/4 :296-302,2012
  • Revision and update on clinical practice guideline for liver cirrhosis.
    The Korean Journal of Hepatology 18/1 :1-21,2012
  • The significance of ICG-R15 in predicting hepatic toxicity in patients receiving radiotherapy for hepatocellular carcinoma
    LIVER INTERNATIONAL 32/7 :1165-1171,2012
  • Prediction of Esophageal Variceal Bleeding in B-Viral Liver Cirrhosis Using the P2/MS Noninvasive Index Based on Complete Blood Counts.
    DIGESTION 86/3 :264-272,2012
  • N-3 polyunsaturated fatty acid attenuates cholesterol gallstones by suppressing mucin production with a high cholesterol diet in mice
    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 27/11 :1745-1751,2012
  • CD11b+ Gr1+ Bone Marrow Cells ameliorate liver fibrosis by producing interleukin-10 in mice
    HEPATOLOGY 56/5 :1902-1912,2012
  • Quasispecies and Pre-Existing Drug-Resistant Mutations of Hepatitis B Virus in Patients with Chronic Hepatitis B
    GUT AND LIVER 7/3 :329-334,2013
  • Survival of hepatocellular carcinoma patients may be improved in surveillance interval not more than 6 months compared with more than 6 months; A 15-year prospective study
    JOURNAL OF CLINICAL GASTROENTEROLOGY 47/6 :538-544,2013
  • Efficacy and safety of entecavir plus carnitine complex (GODEX?) compared to entecavir monotherapy in patient with ALT elevated chronic hepatitis B: randomized, multicenter open-label trials. The GOAL study.
    Clinical and Molecular Hepatology 19/2 :165-172,2013
  • Antiviral efficacies of currently available rescue therapies for multidrug-resistant chronic hepatitis B
    Clinical and Molecular Hepatology 19/1 :29-35,2013
  • A pilot study of autologous CD34-depleted bone marrow mononuclear cell transplantation via the hepatic artery in five patients with liver failure
    CYTOTHERAPY 15/12 :1571-1579,2013
  • Survival of Hepatocellular Carcinoma Patients May be Improved in Surveillance Interval not More Than 6 Months Compared With More Than 6 Months: A 15-Year Prospective Study
    JOURNAL OF CLINICAL GASTROENTEROLOGY 47/6 :538-544,2013
  • Quasispecies and Pre-Existing Drug-Resistant Mutations of Hepatitis B Virus in Patients with Chronic Hepatitis B
    GUT AND LIVER 7/3 :329-334,2013
  • Impact of postoperative hepatitis B virus reactivation in hepatocellular carcinoma patients who formerly had naturally suppressed virus
    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 29/5 :1019-1027,2014
  • Prognosis of hepatocellular carcinoma patients with extrahepatic metastasis and the controllability of intrahepatic lesions
    CLINICAL & EXPERIMENTAL METASTASIS 31/4 :475-482,2014
  • Assessment of Hepatic Fibrosis Regression by Transient Elastography in Patients with Chronic Hepatitis B Treated with Oral Antiviral Agents
    JOURNAL OF KOREAN MEDICAL SCIENCE 29/4 :570-575,2014
  • Long-term outcomes of chronic hepatitis B virus infection in the era of antiviral therapy in Korea
    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 29/5 :1005-1011,2014
  • Progression of diet induced nonalcoholic steatohepatitis is accompanied by increased expression of kruppel-like-factor 10 in mice
    JOURNAL OF TRANSLATIONAL MEDICINE 12/186 :1-11,2014
  • Hepatitis C Virus Attenuates Interferon-Induced Major Histocompatibility Complex Class I Expression and Decreases CD8+ T Cell Effector Functions
    GASTROENTEROLOGY 146/5 :1351-1360,2014
  • Clinical outcomes and prognostic factors of patients with advanced hepatocellular carcinoma treated with sorafenib as first-line therapy: A Korean multicenter study
    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 29/7 :1463-1469,2014
  • Concurrent Chemoradiotherapy Shows Long-Term Survival after Conversion from Locally Advanced to Resectable Hepatocellular Carcinoma
    YONSEI MEDICAL JOURNAL 55/6 :1489-1497,2014
  • Omega-3 polyunsaturated fatty acid and ursodeoxycholic acid have an additive effect in attenuating diet-induced nonalcoholic steatohepatitis in mice
    EXPERIMENTAL AND MOLECULAR MEDICINE(Korean journal of biochemistry) 46/e127 :1-7,2014
  • Individual prediction model for lamivudine treatment response in hepatitis B virus e antigen-positive chronic hepatitis B patients
    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 29/5 :1049-1055,2014
  • Efficacy and safety of pegylated interferon base treatment in patients with chronic hepatitis C on dialysis.
    EUROPEAN JOURNAL OF INTERNAL MEDICINE 26/4 :292-296,2015
  • Usefulness of the Controlled Attenuation Parameter for Detecting Liver Steatosis in Health Checkup Examinees
    GUT AND LIVER 9/3 :405-410,2015
  • High-Dose Vitamin C Promotes Regression of Multiple Pulmonary Metastases Originating from Hepatocellular Carcinoma
    YONSEI MEDICAL JOURNAL 56/5 :1449-1452,2015
  • Effect of eicosapentaenoic acid on cholesterol gallstone formation in C57BL/6J mice
    MOLECULAR MEDICINE REPORTS 11/1 :362-366,2015
  • Liver injury in acute hepatitis A is associated with decreased frequency of regulatory T cells caused by Fas-mediated apoptosis
    GUT 64/8 :1303-1313,2015
  • A single adenovirus-mediated relaxin delivery attenuates established liver fibrosis in rats.
    JOURNAL OF GENE MEDICINE 18/1-3 :16-26,2016
  • Discrimination of Nonalcoholic Steatohepatitis Using Transient Elastography in Patients with Nonalcoholic Fatty Liver Disease
    PLOS ONE 11/6 :e0157358-,2016
  • Clinicopathological features of choledocholithiasis patients with high aminotransferase levels without cholangitis
    MEDICINE 95/42 :e5,176-,2016
  • Clinical Utility of a New Automated Hepatitis C Virus Core Antigen Assay for Prediction of Treatment Response in Patients with Chronic Hepatitis C
    JOURNAL OF KOREAN MEDICAL SCIENCE 31/9 :1,431-1,437,2016
  • Transplantation With Autologous Bone Marrow-Derived Mesenchymal Stem Cells for Alcoholic Cirrhosis: Phase 2 Trial
    HEPATOLOGY 64/6 :2,185-2,197,2016
  • KASL clinical practice guidelines: management of chronic hepatitis B
    Clinical and molecular hepatology 22/1 :18-75,2016
  • Platelet-derived growth factor receptor α in hepatocellular carcinoma is a prognostic marker independent of underlying liver cirrhosis
    ONCOTARGET 8/24 :39,534-39,546,2017
  • Factors affecting survival after concurrent chemoradiation therapy for advanced hepatocellular carcinoma: a retrospective study
    RADIATION ONCOLOGY 12/133 :1-8,2017
  • Long-Term Follow-Up of Patients after Autologous Bone Marrow Cell Infusion for Decompensated Liver Cirrhosis
    CELL TRANSPLANTATION 26/6 :1,059-1,066,2017
  • Real-life prevalence of resistance-associated variants against non-structural protein 5A inhibitors and efficiency of Daclatasvir + Asunaprevir therapy in Korean patients with genotype 1b hepatitis C
    VIROLOGY JOURNAL 14/164 :1-9,2017
  • Antiviral Therapy in Patients With Chronic Hepatitis C-related Hepatocellular Carcinoma Responding to Palliative Treatment
    JOURNAL OF CLINICAL GASTROENTEROLOGY 52/6 :557-562,2018
  • Selective deletion of hepatocyte platelet-derived growth factor receptor α and development of liver fibrosis in mice
    CELL COMMUNICATION AND SIGNALING 16/1 :93-103,2018

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